Allergic reactions can occur with any drug. Patients need to be constantly asked about allergic reactions, and notes/warnings/flags about allergies must be posted on all medical, health, pharmacy, and dental records. Some drugs cause allergies more than others, and patients with multiple allergies are at risk for more allergies and more severe reactions. Allergic reactions can be minor, a rash, itching, or severe/deadly, an anaphylaxis – unable to breath, loss of pulse, or severe swelling/ rash on the skin. The minor reactions, with no prior reaction hisory, are unavoidable. They are important, and must be noted, because the second or subsequent exposures can result in a severe or deadly reaction. As a result of this, severe reactions are, in most cases, avoidable. The video, presented by James T. O’Donnell Pharm D, discusses allergic reactions, risks, avoidance, and provides guidances for risk reduction of this very common and frequently deadly adverse drug reaction.