James J. O’Donnell

Curriculum Vitae, PDF Version

Experience

Pharmaconsultant, Inc.

Vice President—Research and Development, Consultant in pharmacology and analytical toxicology                                                                                            8/15 – Present

Indiana University School of Medicine—South Bend

            Postdoctoral Fellow                                                           7/14-7/15

University of Chicago Department of Medicine

Section of Pulmonary and Critical Care (Respiratory Biology Training Grant)

Postdoctoral Fellow                                                  5/14/12-5/13/14

Rush University Medical Center

Department of Pharmacology

Research Associate                                          1/1/12-4/12

University of Wisconsin-Madison

Graduate Research Assistant in organometallic chemistry      2003 – 2005

Northwestern University

Research Assistant in organometallic/polymer chemistry              2002 – 2003

Education

 

Rush University Medical Center

Ph.D., Department of Pharmacology                                    2006-2011

Advisor:  Dr. Hazel Lum

Project: “P120 Catenin Suppresses the Inflammatory Response in Endothelial Cells”

University of Wisconsin-Madison

Masters of Science, Chemistry                                           2003-2005

Northwestern University

             Special Student in Chemistry              2001-2003

Massachusetts Institute of Technology (MIT)

            B.S. Electrical Engineering and Computer Science                   1996-2001

 

Awards

University of Chicago Department of Medicine Research Day

Best Abstract, Translational Medicine/Fellow Category               2013

 

Rush University

Paul E. Carson, MD Award for Excellence in Pharmacology               2012

Sigma Xi Poster Competition, 3rd out of 63 students at Rush University Research Forum 2010

 

Other

National Merit Scholarship Winner (awarded to top 2,000 students in U.S.A.
by National Merit Scholarship Corporation)                                  1996

 

Professional Organizations

American Academy of Clinical Toxicology (AACT)                            2015-present

American Society for Pharmacology and Experimental Therapeutics (ASPET)  2013-present

American Physiological Society (APS)                                              2008-2011

American College of Clinical Pharmacology (ACCP                           2015-present

 

 

Teaching Experience

Rush University Medical Center (2008-present)

Mechanisms of Disease (2nd year Medical School)

Pharmacokinetics               2013-2015

Medical Pharmacology (2nd year Medical School)                                Pharmacokinetics               2008-2015

Safety Pharmacology                                                               10/15

Neurological Clinical Medicine and Pharmacology (HPTH644-15SP)    2015

Introduction to Medical Pharmacology with Medical Physiology,                                              2011

(course for all students in PhD, physician assistantship (P.A.), and biotechnology programs); taught Pharmacokinetics

Advanced Pharmacokinetics    2010

taught course to 2nd year Pharmacology graduate students

 

Rosalind Franklin University (2013-present)

General Pharmacology of the CNS                4/15

Advanced Clinical Medicine                         2015

(Pharmacology component for physical therapy program)

Analgesics and DMARDS            10/14

NSAIDs and Glucocorticoids       10/14

Advanced Clinical Medicine and Pharmacology (HPTH 724),                                    2013

Advanced Clinical Medicine and Pharmacology (HPTH 724)

Lecturer (5 lecture hours, physical therapy students)

NSAIDs and Glucocorticoids        9/13

Analgesics                                9/13

Muscle Relaxants and Local Anesthesia             10/13

Medications for Traumatic Brain Injury (TBI) and Other Neurological                                 10/13

Conditions

Cardiovascular Pharmacology    10/13

 

University of Wisconsin-Madison

Teaching Assistant for General Chemistry    2003-2005

 

Programs attended

American College of Medical Toxicology Seminars in Forensic Toxicology: a Legal “Potpourri” (marijuana/alcohol) Denver, CO, 12/15

MRO and Beyond: Advanced Drug Testing Interpretation (American College of Medical Toxicology Annual Scientific Meeting, Satellite Session) Huntington Beach, CA 3/16

 

Service

Reviewer, Microvascular Research (2016-present)

Reviewer, American Journal of Therapeutics (2013-present)

Reviewer, PLoS One (2014)

Poster Session Judge, American Society for Pharmacology and Experimental Therapeutics-Great Lakes Chapter     (ASPET-GLC) Annual Meeting (2015)

Councilor, American Society for Pharmacology and Experimental Therapeutics, Great Lakes Chapter (ASPET-GLC) (2013-2015)

Activities Coordinator, Graduate Student Council (2006-2008)

-coordinated silent auction and participated in other facets of running Emerald Ball fundraiser event (2007-2008)

 

 

publications

  1. O’Donnell, J.T., O’Donnell III, J.J. eds. Drug Injury. 4th ed. Tucson, AZ: Lawyers & Judges Publishing Company, Inc.; (in press)
  2. O’Donnell III, J.J., O’Donnell, J.T., Juettner V. General Principles of Pharmacology. In: O’Donnell J.T., O’Donnell III, J.J., eds. Drug Injury. 4th ed. Tucson, AZ: Lawyers & Judges Publishing Company, Inc.: (in press)
  3. O’Donnell, J.T., O’Donnell III, J.J. Allergic Drug Reactions. In: O’Donnell J.T., O’Donnell III, J.J. eds. Drug Injury. 4th ed. Tucson, AZ: Lawyers & Judges Publishing Company, Inc.: (in press)
  4. O’Donnell, J.T., Marks, D.H., Danese, P., and O’Donnell III, J.J. Drug-induced Liver Disease. In: O’Donnell J.T., O’Donnell III, J.J. eds. Drug Injury. 4th ed. Tucson, AZ: Lawyers & Judges Publishing Company, Inc.: (in press)
  5. O’Donnell, J.T., O’Donnell III, J.J. Dangers of Opiates. In: O’Donnell J.T., O’Donnell III, J.J. eds. Drug Injury. 4th ed. Tucson, AZ: Lawyers & Judges Publishing Company, Inc.: (in press)
  6. O’Donnell III, J.J., O’Donnell, J.T. Drug-induced Falls. In: O’Donnell J.T., O’Donnell III, J.J., eds. Drug Injury. 4th ed. Tucson, AZ: Lawyers & Judges Publishing Company, Inc.: (in press)
  7. O’Donnell III, J.J., O’Donnell, J.T., ImobergSted, A. Drug Testing in the Workplace. In: O’Donnell J.T., O’Donnell III, J.J., eds. Drug Injury. 4th ed. Tucson, AZ: Lawyers & Judges Publishing Company, Inc.: (in press)
  8. O’Donnell, J.T., O’Donnell III, J.J. Alcohol. In: O’Donnell J.T., O’Donnell III, J.J., eds. Drug Injury. 4th ed. Tucson, AZ: Lawyers & Judges Publishing Company, Inc.: (in press)
  9. O’Donnell, J.T., O’Donnell III, J.J., Benjamin, D.M. Marijuana: Pharmacology and Medical-Legal Issues. In: O’Donnell J.T., O’Donnell III, J.J., eds. Drug Injury. 4th ed. Tucson, AZ: Lawyers & Judges Publishing Company, Inc.: (in press)
  10. Tian, Y.; Gawlak, G.; O’Donnell III, J.J.; Birukova, A.A.; Birukov, K.G.; Activation of VEGF receptor-2 mediates endothelial permeability caused by cyclic stretch. Manuscript submitted.
  11. Gawlak, G.; Son, S.; Tian, Y.; O’Donnell III, J.J.; Birukov, K.; Birukova, A; Chronic high magnitude cyclic stretch stimulates EC inflammatory response via VEGF Receptor 2 dependent mechanism. Manuscript submitted.
  12. Birukova, A.; Tian, Y.; Gawlak, G.; O’Donnell III, J.J.; Mambetsariev, I.; Modulation of endothelial inflammation by low and high magnitude cyclic stretch. Manuscript submitted.
  13. Tian, Y.; Tian, X.; Gawlak, G.; O’Donnell III, J.J.; Sacks, D.B.; and Birukova, A.B.; IQGAP1 regulates endothelial barrier function via EB1 – cortactin crosstalk. Mol Cell Biol. 2014 Sep 15;34(18):3546-58.
  14. O’Donnell III, J.J.; Birukova, A.A.; Beyer, E.C.; Birukov, K.G., 2014. Gap Junction Protein Connexin 43 (Cx43) Exacerbates Lung Vascular Permeability. PLoS One. 2014 Jun 26;9(6):e100931.
  15. Gawlak, G., Tian, Y.; O’Donnell III, J.J.; Tian, X.; Birukova, A.A.; and Birukov, K.G. Paxillin mediates stretch-induced Rho signaling and endothelial permeability via assembly of paxillin – p42/44MAPK – GEF-H1 complex. FASEB J. 2014 Jul; 28(7):3249-60.
  16. Cowan, C.; O’Donnell III, J.J.; Lum, H.; and Xu, S.; MicroRNA-146 Inhibits Thrombin-induced NF-κB Activation and Subsequent Inflammatory Responses in Human Retinal Endothelial Cells. 2014. Invest Ophthalmol Vis Sci. 2014 Jul 1;55(8):4944-51.
  17. O’Donnell III, J.J.; Zhuge, Y.; Holian, O.; Cheng, F; Thomas L. L.; Forsyth C. B.; Lum, H.,   Loss of P120 Catenin Upregulates Transcription of Pro-inflammatory Adhesion Molecules in Human Endothelial Cells. Microvasc Res. 82(2), 105-12.
  18. Zhang, J.; O’Donnell III, J. J.; Holian, O.; Vincent, P.A.; Kim, K.S.; Lum, H., 2010. P120 Catenin Represses Transcription through Kaiso in Endothelial Cells. Res. 80(2), 233-9.
  19. Jensen, T.R.; O’Donnell III, J. J.; Marks, T.J. 2004. Do/fn-Mediated Ring-Opening Ziegler Polymerization (ROZP) and Copolymerization with Mono- and Disubstituted Methylenecyclopropanes.  Diverse Mechanisms and a New Chain-Capping Termination Process.   23(4), 740-754.
  20. Seyam, A.M.; Stubbert, B.D.; Jensen, T.R.; O’Donnell III, J.J.; Stern, C.L.; Marks, T.J. 2004. Organolanthanide Constrained Geometry Complexes Modified for Catalysis: Synthesis, Structure, and Aminoalkane Hydroamination Properties of a Pyrrolidine-substituted Constrained Geometry Organolutetium Complex. Inorganica Chimica Acta, 357, 4029-4035.
  21. O’Donnell, J. J.; Zhang, J.; Forsyth, C.; Lum, H., 2009. Intracellular movement of p120-catenin in Endothelial Cells and Implications for Transcriptional Regulation. FASEB J. 23, 1028.2, (abstract)
  22. Lum, H.; Cheng, F. O’Donnell, J. J.; Im, H.; and Holian, O., 2009. Adherens Junction Protein, P120 Catenin, Represses Transcriptional Activity of Endothelial Cells. FASEB J. 23:1028.3. (abstract)
  23. Review Publications/Book Chapters
  24. Benjamin D, O’Donnell JT and O’Donnell JJ. Pharmacology and Toxicology of Marijuana in, Legal Medicine and Medical Ethics, 9th Edition, American College of Legal Medicine, 2015.
  25. O’Donnell JT and O’Donnell JJ. Pharmacology of Marijuana, in Tiftickjian J. Medical Legal Aspects of Marijuana – Colorado Edition. L&J Publishers, Tucson, 2015.
  26. O’Donnell JT and O’Donnell JJ. Alcohol in Civil Litigation. In Caplan Y and Goldberger B, Garriott’s Medicolegal Aspects of Alcohol, 6th Edition, October 2014.
  27. O’Donnell JT, Marks D.H., Danese P., and O’Donnell III JJ, Marks DM. Drug Induced Liver Disease: Primer for the Primary Care Physician. DILD Vol 60, No 2 pages 49-104 Feb 2014 ISSN 0011-5029
  28. O’Donnell III J.J., O’Donnell JT, and Juettner VM. 2012 Basic Pharmacology in Drug Injury: Liability, Analysis, and Prevention, 3rd L&J Publ, Tucson
  29. O’Donnell III JJ, O’Donnell JT and Juettner VM. 2012. Clinical Pharmacology for the Primary Care Physician. Disease-a-Month, October 2012.Elsevier.

              

 

Conferences/Departmental Seminars

  1. 3/2016, Traffic Law CLE, Northwest Suburban Bar Association, DUI and Prescription Drugs, Arlington Heights, IL.
  2. 3/2016, Traffic Law CLE, Northwest Suburban Bar Association, Retrograde Extrapolation, Arlington Heights, IL.
  3. 4/2014, Indiana University School of Medicine Seminar, Gap Junction Protein Connexin 43 (Cx43) Exacerbates Lung Vascular Permeability; South Bend, IN. O’Donnell III, J.J. (Invited Talk)
  4. 2/2014, Haim and Jane Graumann Nagirner Weinstein Centennial Symposium Series, Rosalind Franklin University. Gap Junction Protein Connexin 43 (Cx43) Exacerbates Lung Vascular Permeability; Chicago, IL. O’Donnell III, J.J. (Invited Talk)
  5. 7/2013, International Gap Junction Conference, Gap Junction Protein Connexin 43 (Cx43) Exacerbates Lung Vascular Permeability. Charleston, SC. O’Donnell III, J.J.; Birukova, A.A.; Beyer, E.C.; Birukov, K.G. (Invited Talk)
  6. 6/2013, American Society for Pharmacology and Experimental Therapeutics (ASPET) Great Lakes Chapter Meeting, Gap Junction Protein Connexin 43 (Cx43) Exacerbates Lung Vascular Permeability. Chicago, IL.  O’Donnell III, J.J.; Birukova, A.A.; Beyer, E.C.; Birukov, K.G.
  7. 5/2013, American Thoracic Society Conference, Gap Junction Protein Connexin 43 (Cx43) Exacerbates Lung Vascular Permeability. Philadelphia, PA. O’Donnell III, J.J.; Birukova, A.A.; Beyer, E.C.; Birukov, K.G.
  8. 2/2013, Rush University Pharmacology Department Seminar, The Role of Connexins in the Regulation of Endothelial Permeability. Chicago, IL. O’Donnell III, J.J. (invited)
  9. 5/2011, Chicago Signal Transduction Symposium, Loss of P120ctn Upregulates Transcription of Pro-inflammatory Adhesion Molecules in Human Endothelial Cells. Chicago, IL. O’Donnell III, J.J.; Zhuge, Y.; Cheng, F.; Thomas, L.L.; Forsyth, C. B.; Lum, H.
  10. 5/2011, Rush University Research Forum. Loss of P120ctn Upregulates Transcription of Pro-inflammatory Adhesion Molecules in Human Endothelial Cells. Chicago, IL. O’Donnell III, J.J.; Zhuge, Y.; Cheng, F.; Thomas, L.L.; Forsyth, C. B.; Lum, H.
  11. 3/2011, Rush University Pharmacology Department Seminar, Loss of P120 Catenin Upregulates Transcription of Pro-inflammatory Adhesion Molecules in Human Endothelial Cells. Chicago, IL. O’Donnell, J.J.
  12. 4/2010, Rush University Research Forum, P120 Catenin Suppresses the Inflammatory Response in Endothelial Cells. Chicago, IL. O’Donnell, J.J.; Cheng, F.; Zhang, J.; Zhuge, Y.; Holian, O.; Lum, H.
  13. 4/2010, Experimental Biology Conference, P120 Catenin Suppresses the Inflammatory Response in Endothelial Cells. Anaheim, CA. O’Donnell, J.J.; Cheng, F.; Zhuge, Y.; Zhang, J.; Holian, O.; Lum, H.
  14. 2/2010, Rush University Pharmacology Department Seminar, P120 Catenin Suppresses the Inflammatory Response in Endothelial Cells. Chicago, IL. O’Donnell, J.J.
  15. 3/2009, Experimental Biology Conference, Nuclear Translocation of P120-catenin in Endothelial Cells and Implications for Transcriptional Regulation. New Orleans, LA, O’Donnell, J. J.; Zhang, J.; Forsyth, C.; Lum, H.
  16. 3/2009, Experimental Biology Conference, Adherens Junction Protein, P120 Catenin, Represses Transcriptional Activity of Endothelial Cells. New Orleans, LA. Lum, H.; Cheng, F.; O’Donnell, J. J.; Im, H.; Holian, O.
  17. 5/2009, Rush University Pharmacology Department Seminar, Intercellular Movement of P120-catenin in Endothelial Cells: Implications for Transcription Regulation. Chicago, IL. O’Donnell, J.J.
  18. 4/2009, Rush University Research Forum, Intracellular Movement of P120-catenin in Endothelial Cells and Implications for Transcriptional Regulation. Chicago, IL. O’Donnell, J.; Zhang, J.; Forsyth, C.; Lum, H.
  19. 4/2009, Rush University Research Forum, Adherens Junction Protein, P120 Catenin, Suppresses Transcription of Inflammatory Genes in Human Microvascular Endothelial Cells. Chicago, IL. Cheng, F.; O’Donnell III, J.J.; Im, H.J.; Holian, O.; Kim, K.S.; Lum, H.
  20. 5/2008, Rush University Pharmacology Department Seminar, Junctional Protein P120 Catenin Enhances Barrier Function and Represses Transcription in Endothelial Cells. Chicago, IL. O’Donnell, J.J.
  21. 4/2008, Rush University Research Forum, Junctional Protein P120 Catenin Enhances Barrier Function and Represses Transcription in Endothelial Cells. Chicago, IL. O’Donnell III, J. J.; Cheng, F.; Zhang, J.; Holian, O.; Predescu, S.; Lum, H.
  22. 5/2007, Rush University Pharmacology Department Seminar, Role of P120 Catenin in the Regulation of Kaiso-mediated Transcription Repression in Endothelial Cells, Chicago, IL. O’Donnell, J.J.
  23. 9/2006, Rush University Pharmacology Department Seminar, Role of P120 Catenin in the Regulation of Kaiso-mediated Transcription Repression in Endothelial Cells, Chicago, IL. O’Donnell, J.J.


 

Selected Laboratory techniques

Analytical Chemistry: method validation for analytical instrumentation, nuclear magnetic resonance (nmr) spectroscopy, gas chromatography (GC), mass spectrometry (MS), high performance liquid chromatography (HPLC), Liquid chromatography/mass spectrometry (LC/MS), infrared spectrometry, thermal gravimetric analysis (TGA), differential scanning calorimetry (DSC), thin layer chromatography (TLC)

Synthetic Chemistry: air-free chemistry for organometallic synthesis (Schlenk line, glovebox), organic synthetic chemistry

Bioinformatics/Computer skills:

QIIME, UNIX, python, R, Excel, SPSS, Reference Manager, Mathcad, Powerpoint, Microsoft Word

Molecular biology:

molecular cloning and subcloning, DNA gel electrophoresis, RNAi technology, RT-PCR (with primer design,) RNA/DNA concentration measurement with Nanodrop

Protein work:

SDS-PAGE, Western blot, protein concentration determination

Imaging techniques:

immunofluorescence, immunohistochemistry, confocal microscopy, live imaging, Licor/Odyssey

Animal models:

intraperitoneal and subcutaneous injection, submandibular bleed, cardiac exsanguination, euthanasia, restraint.

Cell culture:

transfection, endothelial cell types (HPAEC, PMVEC, HBMEC, BPAEC)

Specialized techniques:

Luciferase reporter assay, dye transfer assay (gap junction function), dye uptake assay (hemichannel function), neutrophil isolation and adhesion assay, electrical cell-substrate impedance signaling (ECIS) for monitoring barrier function, cyclic stretch, adenovirus infection, UV spectroscopy